N-Boc-L-LEUCINE MONOHYDRATE

PRODUCT IDENTIFICATION
CAS NO. 13139-15-6

N-Boc-L-LEUCINE

EINECS NO.

236-073-2

FORMULA C11H21NO4
MOL WT. 231.29

H.S. CODE

 2922.49

TOXICITY

  
SYNONYMS N-alpha-t-BOC-L-Leucine Hydrate; BOC-Leu-OH·H2O;
N-tert-Butoxycarbonyl-L-leucine Hydrate; Boc-Leu monohydrate; BOC-L-Leucine Monohydrate; N-[(1,1-Dimethylethoxy)carbonyl]-L-leucine Hydrate; N-alpha-t-BOC-L-leucine Hydrate;
DERIVATION

 

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE White to off-white crystalline powder
MELTING POINT 82 - 87 C
BOILING POINT

 

SPECIFIC GRAVITY  
SOLUBILITY IN WATER

 

pH  
VAPOR DENSITY

 

AUTOIGNITION

  

NFPA RATINGS

 Health: 1; Flammability: 0; Reactivity: 0

REFRACTIVE INDEX

 

FLASH POINT

 

STABILITY

Stable under ordinary conditions. Moisture and light sensitive

GENERAL DESCRIPTION & APPLICATIONS
Valine, Isoleucine and Leucine are all branched-chain amino acids which can be burned for fuel in the cells to promotes muscle recovery when in balance with each other most effective. Only the L-stereoisomers appear in mammalian protein. They play a role in wound healing and the growth of new tissue. These branched amino-acids are needed to increase the bio-availability of complex carbohydrate intake and are absorbed by the muscle cells for anabolic muscle building activity. Branched amino-acids (Valine, Isoleucine and Leucine ) with tryptophan and phenylalanine (aromatic side chain amino acids) contribute to the structure of protein by the tendency of its side chain composed only of carbon and hydrogen to participate in hydrophobic interactions which determines the tertiary structure of the peptide chain. Isoleucine, chemically 2-amino-3-methylvaleric acid, is a monocarboxylic amino acid occurring in most dietary proteins. It is necessary for optimal growth in infants and for nitrogen equilibrium in human adults. Leucine, chemically 2-amino-4-methylvaleric acid, is the isomer of isoleucine. Their methyl branch positions are difference, which show different properties of them. Norleucine, chemically 2-aminohexanoic acid, is the unbranched isomer.  The prefix nor- describes normal structure which has no branched chain of carbon atoms. (In case of norepinephrine, it has one less methylene group than its homologue, epinephrine). Norleucine is a nonessential amino acid extracted from the leucine fraction of the decomposition of the proteins of nervous tissue. Commercial norleucine is synthesized for peptidomimetics to prepare unnatural and unusual amino acids and amino acid analogs as well as to modify peptides. N-alpha-t-BOC-L-Leucine is an unnatural amino acid for peptidomimetics and biological research.
SALES SPECIFICATION

APPEARANCE

 White to off-white crystalline powder

ASSAY

 98.5 - 100.5%
OPTICAL ROTATION [a]20 -24.0° ~ -26.0° (C=2 in CH3COOH)
SOLUTION CLARITY

clear

WATER

7.0 - 8.0%

Fe

10ppm max
HEAVY METALS

10ppm max

As

2ppm max
LOSS ON DRYING

0.5% max
TRANSPORTATION
PACKING
 
HAZARD CLASS Not regulated
UN NO.  
OTHER INFORMATION
Hazard Symbols: n/a, Risk Phrases: n/a, Safety Phrases: 24/25-28A-37-45

GENERAL DESCRIPTION OF AMINO ACID

Amino Acid

Abbreviation

Formula (Mol WT)

pK1

pK2

pKR

pI

Hydropathy Index

3-Letters

1-Letter

-COOH

-NH3+

R group
Alanine

Ala

A

 C3H7NO2 (89.09)

2.34

9.69

-

6.00

1.8
Arginine

Arg

R

 C6H14N4O2(174.20)

2.17

9.04

12.48

10.76

-4.5
Asparagine

Asn

N

 C4H8N2O3(132.12)

2.02

8.80

-

5.41

-3.5
Aspartic Acid

Asp

D

 C4H7NO4(133.10)

1.88

9.60

3.65

2.77

-3.5
Cysteine

Cys

C

 C3H7NO2S(240.30)

1.96

10.128

8.18

5.07

2.5
Glutamic Acid

Glu

E

 C5H9NO4(147.13)

2.19

9.67

4.25

3.22

-3.5
Glutamine

Gln

Q

 C5H10N2O3(146.15)

2.17

9.13

-

5.65

-3.5
Glycine

Gly

G

 C2H5O2(75.07)

2.34

9.60

-

5.97

-0.4
Histidine

His

H

 C6H9N3O2(155.16)

1.82

9.17

6.00

7.59

-3.2
Isoleucine

Ile

I

 C6H13NO2(131.18)

2.36

9.60

-

6.02

4.5
Leucine

Leu

L

 C6H13NO2(131.18)

2.36

9.60

-

5.98

3.8
Lysine

Lys

K

 C6H14N2O2(146.19)

2.18

8.95

10.53

9.74

-3.9
Methionine

Met

M

 C5H11NO2S(149.21)

2.28

9.21

-

5.74

1.9
Phenylalanine

Phe

F

 C9H11NO2(165.19)

1.83

9.13

-

5.48

2.8
Proline

Pro

P

 C5H9NO2(115.13)

1.99

10.60

-

6.30

1.6
Serine

Ser

S

 C3H7NO3(105.19)

2.21

9.15

-

5.58

-0.8
Threonine

Thr

T

 C4H9NO3(119.12)

2.09

9.10

-

5.60

-0.7
Tryptophan

Trp

W

 C11H10N2O2(204.23)

2.83

9.39

-

5.89

-0.9
Tyrosine

Tyr

Y

 C9H11NO3(181.19)

2.20

9.11

10.07

5.66

-1.3
Valine

Val

V

 C5H11NO2(117.15)

2.32

9.62

-

5.96

4.2